Thrombolysis was associated with a lower rate of complications (5%) compared to non-thrombolysed patients (57%) among those hospitalized for ST-segment elevation acute coronary syndrome.
Cross-Sectional (n=207)
No
Does intravenous thrombolysis with streptokinase improve reperfusion and reduce complications in patients with acute coronary syndrome with ST elevation?
In a resource-limited setting, thrombolysis with streptokinase for STEMI was associated with high reperfusion rates and significantly fewer complications compared to no thrombolysis.
Absolute Event Rate: 5% vs 57%
Introduction: Acute myocardial infarction (IDM) occupies the first place in terms of mortality, among ischemic pathologies. Thrombolysis in the case of medical treatment for acute myocardial infarction (AMI) is undoubtedly the most revolutionary performed to date in this context, with a significant reduction in the mortality rate. The aim of our study was to describe the epidemiological aspects, the criteria for myocardial reperfusion post thrombolysis, the complications during thrombolysis and the complications of acute myocardial infarction in the cardiology department of the CHU Ernesto Guevara De La Serna of Las Tunas (Cuba). Methods: A retrospective cross-sectional descriptive study was carried out from June 2009 to December 2011. The patients hospitalized during this period in the USIC (coronary intensive care unit) for SCA ST(+) were included in the study. The variables studied were: Age, sex, myocardial reperfusion criteria, complications during thrombolysis and complications of myocardial infarction. Results: A total of 207 patients were included. The male sex represented 72.5% of the cases, giving a sex ratio of 2.63. The age group > 60 years was predominant with 54.2% of the cases. Thrombolysed patients represented 65.2% of the cases. Myocardial reperfusion criteria were observed in the majority of thrombolysed patients: relief of precordial pain (77%), regression of the ST segment to 50% of its previous level (81.5% of patients). Bleeding was observed in 1.5% of thrombolysed cases. Complications were encountered in 57% of non thrombolysed patients with a lethality of 5.6%. Conclusion: The male sex was the most affected. Thrombolysis was effective in the majority of patients. The post thrombolysis bleeding rate was low. More than half of the cases of SCA ST(+) not thrombolysed presented complications.
Sonfo et al. (Wed,) conducted a cross-sectional in Acute Coronary Syndrome ST+ (n=207). Thrombolysis (Streptokinase) vs. Non-thrombolysed patients was evaluated on Complications of acute myocardial infarction. Thrombolysis was associated with a lower rate of complications (5%) compared to non-thrombolysed patients (57%) among those hospitalized for ST-segment elevation acute coronary syndrome.