Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association

Conference Article| May 01 1995 Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association M. D. Houslay; M. D. Houslay 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar G. Scotland; G. Scotland 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar L. Pooley; L. Pooley 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar S. Spence; S. Spence 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar I. Wilkinson; I. Wilkinson 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar F. McCallum; F. McCallum 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar P. Julien; P. Julien 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar N. G. Rena; N. G. Rena 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar A. M. Michie; A. M. Michie 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar S. Erdogan; S. Erdogan 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar L. Zeng; L. Zeng 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar J. C. O'Connell; J. C. O'Connell 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar E. S. Tobias; E. S. Tobias 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar I. MacPhee I. MacPhee 1Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, Biochemistry Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: January 10 1995 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1995 Biochemical Society1995 Biochem Soc Trans (1995) 23 (2): 393–398. https://doi.org/10.1042/bst0230393 Article history Received: January 10 1995 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation M. D. Houslay, G. Scotland, L. Pooley, S. Spence, I. Wilkinson, F. McCallum, P. Julien, N. G. Rena, A. M. Michie, S. Erdogan, L. Zeng, J. C. O'Connell, E. S. Tobias, I. MacPhee; Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association. Biochem Soc Trans 1 May 1995; 23 (2): 393–398. doi: https://doi.org/10.1042/bst0230393 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: cAMP, cyclic AMP, PKA, cAMP-dependent protein kinase, PDE, phosphodiesterase, Met26-RD1, RD1 lacking the N-terminal 25 amino acids, CAT, chloramphenical acetyltransferase © 1995 Biochemical Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.