Key result
Vector flow mapping identified significantly higher left ventricular energy loss during the slow ejection phase in LOHCM patients compared to NOHCM and controls (AUC 0.964, P<0.05).
Why the study?
To assess LV energy loss, circulation, and vortex area using vector flow mapping in patients with latent obstructive and nonobstructive hypertrophic cardiomyopathy.
Can vector flow mapping detect differences in left ventricular energy loss and vortex characteristics between latent obstructive hypertrophic cardiomyopathy, nonobstructive hypertrophic cardiomyopathy, and healthy controls?
Cross-Sectional (n=35)
Can vector flow mapping detect differences in left ventricular energy loss and vortex characteristics between latent obstructive hypertrophic cardiomyopathy, nonobstructive hypertrophic cardiomyopathy, and healthy controls?
Vector flow mapping identifies significantly higher left ventricular energy loss in latent obstructive hypertrophic cardiomyopathy, providing a novel echocardiographic marker for disease severity.
Answers are grounded in this paper and cite their sources.
May distinguish LOHCM phenotypes via vector flow mapping; leaves open validation for risk stratification or management.
OBJECTIVES: This study aimed to assess left ventricular (LV) energy loss (EL), circulation and vortex area using vector flow mapping (VFM) in patients with latent obstructive hyper-trophic cardiomyopathy (LOHCM) and nonobstructive hypertrophic cardiomyopathy (NOHCM). METHODS: Fourteen LOHCM patients, 10 NOHCM patients, and 11 healthy individuals were evaluated by transthoracic echocardiography. An offline VFM workstation was used to analyze the LV blood flow patterns and fluid dynamics. The hemodynamic parameters, EL, circulation, and vortex area in 7 cardiac phases were calculated and analyzed. RESULTS: Compared with controls and NOHCM patients, EL was significantly higher in -LOHCM patients during the rapid ejection phase, slow ejection (SE) phase, and isovolumetric relaxation phase (p < 0.05). LOHCM patients also showed increased circulation during SE compared to the other two groups (p < 0.05). The ability to discriminate between NOHCM and LOHCM was assessed by the area under the receiver-operating characteristic curve (AUC), and EL during SE was found to have the largest AUC (0.964); the best cutoff value was 6.34 J/m3/s, with a sensitivity of 100% and specificity of 80%. CONCLUSIONS: The VFM technique can detect abnormal changes of LV EL and vortex characteristics in hypertrophic cardiomyopathy patients. Compared with controls and NOHCM patients, the LOHCM patients have worse systolic and diastolic functions.
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Zhu et al. (2020) conducted a cross-sectional in Latent obstructive hypertrophic cardiomyopathy (LOHCM) and nonobstructive hypertrophic cardiomyopathy (NOHCM) (n=35). Latent obstructive hypertrophic cardiomyopathy (LOHCM) vs. Nonobstructive hypertrophic cardiomyopathy (NOHCM) and healthy controls was evaluated on Energy loss (EL) during the slow ejection phase (AUC 0.964, p=<0.05). Vector flow mapping identified significantly higher left ventricular energy loss during the slow ejection phase in LOHCM patients compared to NOHCM and controls (AUC 0.964, P<0.05).
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