Recent studies suggest that prostaglandins of the E and F series may cause release of the adenohypophysial hormones, ACTH, growth hormone (GH), prolactin and LH. Evidence for the stimulation of ACTH release from the rat pituitary by prostaglandin has been presented by de Wied, Witter, Versteeg & Mulder (1969); Peng, Six & Munson (1970) and Hedge (1972). Hertelendy, Todd, Ehrhart & Blute (1972) observed that intravenous doses (20 μg/kg) of prostaglandin E1 (PGE1) in castrated rams rapidly induced a significant increase in the plasma concentration of GH. Vermouth & Deis (1972) found that two intraperitoneal injections of PGF2α on Day 18 of pregnancy in rats resulted in a biphasic elevation of plasma prolactin at 12 and 20 hr. Indirect evidence exists which indicates that PGF2α may stimulate LH release in the rat (Labhsetwar, 1970; Orczyk & Behrman, 1972; Varavudhi & Chobdieng, 1972). Systemic infusion of PGF
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Carlson et al. (1973) studied this question.