Of 18 rabbits fed cholesterol for 12 to 104 weeks, 7 developed amyloidosis or paramyloidosis. These rabbits had hyper-globulinemia and their urinary protein contained a high percentage of globulins. Hypertension developed in 4 of 5 rabbits with amyloidosis and in 1 of 7 without such deposits.
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Hoffman et al. (1951) studied this question.
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