February 1, 1992Journal of General Virology

The effect of cicloxolone sodium on the replication in cultured cells of adenovirus type 5, reovirus type 3, poliovirus type 1, two bunyaviruses and Semliki Forest virus

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Population

Cultured cells infected with adenovirus type 5, reovirus type 3, Bunyamwera and Germiston viruses…

Design

Preclinical

Authors

DDDerrick J. DarganMRC University of Glasgow Centre for Virus Research CGC. B. Galt JSJ. H. Subak‐SharpeMRC University of Glasgow Centre for Virus Research

Discussion

Member takes

Implication

No clinical translation yet; leaves open virus-class-specific antiviral development in preclinical models.

Structured PICO

Population

Cultured cells infected with adenovirus type 5 (Ad-5), reovirus type 3 (Reo-3), Bunyamwera and Germiston viruses, poliovirus type 1 (Polio-1) and Semliki Forest virus (SFV)

Intervention

Cicloxolone sodium (CCX) at varying concentrations (e.g., <50 microM, >=100 microM)

Outcome

Virus replication and yieldsurrogate

Cicloxolone sodium demonstrates diverse, virus-specific mechanisms of antiviral activity in cultured cells, including yield reduction and impaired infectivity.

Cite This Study

Dargan et al. (1992) studied this question.

synapsesocial.com/papers/6a7331772bc27536e7c8f3e7 https://doi.org/10.1099/0022-1317-73-2-407

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The effect of cicloxolone sodium on the replication in cultured cells of adenovirus type 5, reovirus type 3, poliovirus type 1, two bunyaviruses and Semliki Forest virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effect of cicloxolone sodium on the replication in cultured cells of adenovirus type 5, reovirus type 3, poliovirus type 1, two bunyaviruses and Semliki Forest virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider