Key result
Higher insulin sensitivity and lower adiposity correlate with increased insulin clearance across diverse populations.
Cross-Sectional (n=1,295)
OBJECTIVE: We aimed to examine insulin clearance, a compensatory mechanism to changes in insulin sensitivity, across sex, race/ethnicity populations, and varying states of glucose tolerance. RESEARCH DESIGN AND METHODS: We measured insulin sensitivity index (S(I)), acute insulin response (AIR), and metabolic clearance rate of insulin (MCRI) by the frequently sampled intravenous glucose tolerance test in 1,295 participants in the Insulin Resistance Atherosclerosis Study. RESULTS: MCRI was positively related to S(I) and negatively to AIR and adiposity across sex, race/ethnicity populations, and varying states of glucose tolerance, adiposity, and family history of diabetes. Differences in MCRI by race/ethnicity (lower in African Americans and Hispanics compared with non-Hispanic whites) and glucose tolerance were largely explained by differences in adiposity, S(I), and AIR. CONCLUSIONS: Insulin sensitivity, insulin secretion, and adiposity are correlates of insulin clearance and appear to explain differences in insulin clearance by race/ethnicity and glucose tolerance status.
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Lorenzo et al. (2012) conducted a cross-sectional in Varying states of glucose tolerance (n=1,295). Insulin sensitivity (SI), acute insulin response (AIR), and adiposity vs. Varying race/ethnicity (African Americans and Hispanics vs. non-Hispanic whites) and glucose tolerance status was evaluated on Metabolic clearance rate of insulin (MCRI). Insulin sensitivity (positively) and acute insulin response and adiposity (negatively) correlated with insulin clearance in 1,295 adults, explaining racial/ethnic and glucose tolerance differences.
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