Key result
Patients with major depressive disorder had significantly higher serum levels of IL-1 beta and TNF-alpha compared to healthy controls, but there was no correlation between inflammatory cytokines, heart rate variability, and vagus nerve morphology.
Why the study?
While functional aspects of the vagus nerves have been studied in major depressive disorder, less is known about morphological alterations and their link to inflammatory cytokines.
Cross-Sectional (n=100)
No
Despite elevated proinflammatory cytokines in patients with major depressive disorder, there is no apparent relationship between these inflammatory markers, heart rate variability, and vagus nerve morphology.
Null vagus nerve findings in MDD urge caution against overinterpreting peripheral inflammation-brain links; leaves open VN morphology's role in depression.
Patients with major depressive disorder (MDD) often show of a low-grade inflammation. Inflammatory cytokines are assumed to be transmitted from the periphery to the brain, amongst others, via the vagus nerves (VN), which constitute a pivotal part of the microbiota-gut-brain axis. While functional aspects of the VNs (heart rate variability (HRV)) were extensively studied in patients with MDD, less is known about morphological alterations. Aim of this study was to examine the relationship between inflammatory cytokines, morphology, and function of the VNs in patients with MDD and healthy controls. Markers of inflammation (tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), and high-sensitive C-reactive protein (hsCRP)) were measured in 50 patients with MDD and 50 age- and sex-matched healthy controls. Inflammatory cytokines were correlated with sonographic characteristics of the VN (cross-sectional area and echogenicity) and with HRV at rest, during standing, and under slow paced breathing. Patients with MDD had significantly higher serum levels of IL-1 beta (0.17 ± 0.13 versus 0.09 ± 1.22 pg/ml, p < 0.001) and of TNF-alpha (0.72 ± 0.23 versus 0.62 ± 0.22 pg/ml, p = 0.013), while levels of hsCRP (1.91 ± 3.02 versus 1.60 ± 2.24 mg/l) were similar between groups. There was a significant correlation between body mass index (BMI) and hsCRP, as well as HRV parameters at rest in all participants. Controlling for the BMI, we found no correlation between inflammatory cytokines, HRV, and morphology of the VNs in patients with MDD. Therefore, further studies are warranted to address the assumed relationship between inflammation, morphology, and function of the VNs in patients with MDD.
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Scheller et al. (2025) conducted a cross-sectional in Major depressive disorder (n=100). Major depressive disorder vs. Healthy controls was evaluated on Serum levels of IL-1 beta (pg/ml) (p=<0.001). Patients with major depressive disorder had significantly higher serum levels of IL-1 beta and TNF-alpha compared to healthy controls, but there was no correlation between inflammatory cytokines, heart rate variability, and vagus nerve morphology.
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