U.V. and U.V. Derivative Spectrophotometric Determination of Two- Component Mixtures

In this paper, two-component mixtures (spironolactone with hydrochlorothiazide, captopril with hydrochlorothiazide, and spironolactone with furosemide) were assayed by U.V. (A), first derivative (dA/dłD) and second derivative (d2A/dłD2) spectrophotometric methods, applying “Zero-Crossing” technique of measurement. The methods were proved using laboratory prepared mixtures. The utility of the methods in assay of dosage forms is also presented.