Key result
Neuroprotective strategies effective in animal brain injury models consistently fail to improve clinical outcomes.
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Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.
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Stocchetti et al. (2015) conducted a review in Acute brain injury (ischemic, hemorrhagic, traumatic, and nontraumatic cerebral lesions). Neuroprotective strategies was evaluated on Secondary tissue loss and functional outcomes. Neuroprotective strategies effective in animal models of acute brain injury have generally yielded disappointing results in human randomized controlled studies (no quantitative data reported).
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