Key result
Combined beta blockade and ACE inhibition improved antioxidative defense, reduced hypertrophy and LVEDP, and enhanced rates of contraction in rats after myocardial infarction.
Why the study?
Does combined beta blockade and ACE inhibition improve myocardial oxidative stress and cardiac function in rats after myocardial infarction?
Does combined beta blockade and ACE inhibition improve myocardial oxidative stress and cardiac function in rats after myocardial infarction?
Combined beta blockade and ACE inhibition reduces myocardial oxidative stress and improves cardiac function in a rat model of myocardial infarction.
Answers are grounded in this paper and cite their sources.
Preclinical data warrant caution against human extrapolation; extends evidence for combined therapy in post-MI oxidative stress models.
In vitro experiments suggest that beta blockade and angiotensin-converting enzyme (ACE) inhibition may protect the failing heart by reduction of myocardial oxidative stress. To test this hypothesis in an in vivo model, the beta blocker metoprolol (350 mg) and the ACE inhibitor ramipril (1 mg) were given either alone or in combination to rats (per kilogram body weight per day) for 6 weeks after myocardial infarction. Left ventricular end-diastolic pressure (LVEDP), contractile function of papillary muscles, enzymatic antioxidative defense (indicated by the activities of the superoxide dismutase isoenzymes and glutathione peroxidase), and the extent of lipid peroxidation were studied. Placebo-treated rats showed cardiac hypertrophy, increased LVEDP, lower rates of contraction and relaxation, as well as a deficit in the myocardial antioxidative defense associated with increased lipid peroxide levels, when compared with sham-operated animals. Combined beta blockade and ACE inhibition improved the antioxidative defense, reduced hypertrophy and LVEDP, and enhanced rates of contraction. Thus prolonged beta blockade and ACE inhibition after infarction may decrease myocardial oxidative stress and thereby could be beneficial in heart failure.
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Theres et al. (2000) studied Myocardial infarction. Metoprolol and ramipril vs. Placebo and sham-operated animals was evaluated on Left ventricular end-diastolic pressure (LVEDP), contractile function, enzymatic antioxidative defense, and lipid peroxidation. Combined beta blockade and ACE inhibition improved antioxidative defense, reduced hypertrophy and LVEDP, and enhanced rates of contraction in rats after myocardial infarction.
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