Primary hypothyroidism presenting as pituitary failure.

Plasma cortisol and growth hormone levels did not rise when hypoglycaemia was induced, but plasma cortisol rose after an intramuscular injection of 5U of vasopressin.Further, the plasma thyroid-stimulating hormone level measured by radioimmunoassay, responded to thyrotrophin-releasing hormone 200 ,g given intra- venously (see table ).No evidence of tumour recurrence was found at operation, and replacement therapy with cortisone, testosterone, and thyroxine produced increased energy, hair growth, and decreased cold sensitivity.