A major fraction of insulin in human and bovine pancreas is readily adsorbed on cationic exchange resin, in sodium form, from homogenates prepared in 0.15 M sodium chloride at pH 6.6 ± 0.4. These studies suggest that this fraction of insulin in pancreas may be in a complex form, possibly with basic proteins, the insulin complex being adsorbed on the resin under specified conditions.
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Antoniades et al. (1960) studied this question.
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