Key result
Circadian misalignment and unbalanced autonomic nervous system activity are proposed to drive the development and progression of non-alcoholic fatty liver disease.
This review highlights the potential role of circadian misalignment and autonomic imbalance in the pathogenesis of non-alcoholic fatty liver disease.
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Hypothesis-generating for circadian-autonomic pathways in NAFLD; should not yet alter clinical practice.
The circadian system, headed by the suprachiasmatic nucleus, synchronizes behaviour and metabolism according to the external light-dark cycle through neuroendocrine and autonomic signals. Metabolic diseases, such as steatosis, obesity and glucose intolerance, have been associated with conditions of circadian misalignment wherein the feeding schedule has been moved to the resting phase. Here we describe the physiological processes involved in liver lipid accumulation and show how they follow a circadian pattern importantly regulated by both the autonomic nervous system and the feeding-fasting cycle. We propose that an unbalanced activity of the sympathetic-parasympathetic branches between organs induced by circadian misalignment provides the conditions for the development and progression of non-alcoholic fatty liver disease.
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Sabath et al. (2015) conducted a review in Non-alcoholic fatty liver disease. Circadian misalignment and autonomic imbalance was evaluated on Development and progression of non-alcoholic fatty liver disease. Circadian misalignment and unbalanced autonomic nervous system activity are proposed to drive the development and progression of non-alcoholic fatty liver disease.
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