Seizure Induced by Insufflation of Bupropion

To the Editor: A 16-year-old boy with a history of depression was brought to the emergency department after he had a generalized, tonic–clonic seizure. His only medication was bupropion (Wellbutrin SR) at a dose of 150 mg twice daily. He reported using marijuana “occasionally” and drinking approximately two 40-oz servings of beer several times a month during the preceding year. He denied using any other illicit substances. The findings on medical evaluation were otherwise unremarkable, and he was discharged with a diagnosis of bupropion-induced seizure. The patient later reported that, approximately one hour before the seizure, he had crushed six . . .