Intravitreous Streptomycin: Its Toxicity and Diffusion

THE discovery of the new antibiotic, streptomycin, by Waksman and his colleagues in 1944, has put at our disposal a substance capable of producing a chemotherapeutic action on organisms not particularly susceptible to other agents.Gram negative organisms and M. tuberculosis are the organisms for which streptomycin is particularly effective.Previous work has shown that streptomycin does not easily penetrate through the cornea (Leopold uand Nichols, 1946) and it was decided to investigate the concentrations of the *