Key result
Pregnancy-driven procoagulant changes elevate thromboembolism risk, while underlying bleeding disorders rarely cause obstetric hemorrhage.
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Normal pregnancy is associated with profound alterations in the coagulation and fibrinolytic systems. While these physiological procoagulant changes are aimed to minimise intrapartum blood loss, they do increase the risk of thromboembolism during pregnancy and the post-partum period. In contrast and more rarely, haemorrhage due to an underlying inherited or acquired bleeding disorder may occur and complicate a pregnancy. Based on an analysis of the literature data, this review presents an overview of the main thrombotic and haemorrhagic disorders complicating pregnancy.
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Massimo Franchini (2006) conducted a review in Thrombotic and haemorrhagic disorders complicating pregnancy. Physiological procoagulant changes in pregnancy increase thromboembolism risk, while underlying bleeding disorders more rarely cause obstetric haemorrhage.
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