Synthesis of the first custom designed cyclodextrins obtained by a nucleophilic attack on hepatkis-2,3-epoxy-β-cyclodextrin is reported. This novel cyclodextrin provides amine functionalities in addition to hydroxyl groups for chemical processes. Spectral evidence shows that the cavity in this new cyclodextrin is flexible and it self assembles into a dimer under specific conditions.
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Khan et al. (1994) studied this question.
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