Why the study?
Does procainamide reduce focal discharges in thoracic veins and atria in a canine model of sustained atrial fibrillation?
Population
Six mongrel dogs with sustained atrial fibrillation induced by 47 +/- 20 days of chronic rapid LA appendage…
Design
Preclinical
Authors
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Hypothesis-generating in canine AF; leaves open translation to human focal trigger suppression.
Does procainamide reduce focal discharges in thoracic veins and atria in a canine model of sustained atrial fibrillation?
Procainamide exerts its anti-fibrillatory effects in a canine model of sustained AF by reducing focal discharges in thoracic veins and the left atrium, with efficacy dependent on inherent pulmonary vein effective refractory period.
Chou et al. (2004) studied this question.
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