Increased neutrophil infiltration as a body-wide effect in pancreatic cancer development

Cancer has long been considered a systemic disease that can actively perturb normal host organs even from distant anatomic sites.1 Such perturbations will likely induce alterations in gene expression and protein networks within those organs that could ultimately affect the organism's physiology1 and may cause tissue damage beyond the tumor itself.2 We now know a great deal of gene expression landscapes in tumor tissues and the adjacent normal tissues. However, our knowledge of other body-wide non-tumor organs is still limited.