Why the study?
Cardiac double-hit and triple-hit lymphomas are rare, studies examining them remain scarce, and triple-hit lymphoma with cardiac involvement has few reported cases.
Primary cardiac triple-hit lymphoma is an extremely rare and aggressive malignancy with a poor prognosis, highlighting the insufficiency of surgical excision alone and the necessity of aggressive chemotherapy.
Right atrial masses may represent THL rather than myxoma; extends sparse case reports but leaves optimal management open.
Cardiac double-hit and triple-hit lymphomas (DHLs, THLs) are rare; in fact, studies examining both DHL and THL remain scarce. THL with cardiac involvement constitutes a rare disease with few cases reported so far. Thus, in this study, we report the case of a 67-year-old woman who presented with initial symptoms of pulmonary embolism. Upon further evaluation, a right atrial mass was detected incidentally, and this was surgically removed under the assumption of a cardiac myxoma. Later, immunohistochemistry analysis of the mass revealed a THL. Aggressive treatment with chemotherapy was necessary; however, the patient refused treatment and had a poor prognosis.
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Salas-Llamas et al. (2022) studied this question.
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