Why the study?
Does aspirin or hyperoxia reduce vasodilation following isometric forearm contraction in healthy volunteers?
Does aspirin or hyperoxia reduce vasodilation following isometric forearm contraction in healthy volunteers?
Prostaglandins make a substantial contribution to the peak vasodilation following isometric contraction of forearm muscles, likely stimulated by endothelial hypoxia.
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Prostaglandin inhibition attenuates contraction-induced vasodilation; confirms their substantial role and extends mechanistic understanding for patient studies.
Win et al. (2005) studied this question.
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