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October 1, 1992Journal of Applied Toxicology

Effect of single gallium arsenide exposure on some biochemical variables in porphyrin metabolism in rats

S.J.S. Flora S. Das Gupta

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Abstract

Gallium arsenide (GaAs) inhibited, dose dependently, delta-aminolevulinic acid dehydratase (ALAD) activity in blood (as observed on days 1, 7 and 15), liver and brain (on day 15) after a single oral treatment. Levels of blood zinc protoporphyrin (ZPP) and urinary delta-aminolevulinic acid (ALA) excretion were elevated on day 7 and day 15 following exposure to 2000 mg kg-1 GaAs. A dose-dependent increase in blood As contents was observed while blood Ga was detectable only at higher doses.

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Flora et al. (1992) studied this question.

synapsesocial.com/papers/6a7385535946a55bc0fb6920 https://doi.org/10.1002/jat.2550120508

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