Why the study?
Does oral carvedilol in escalating doses improve rate or rhythm control in patients with atrial fibrillation and fast ventricular rate?
Does oral carvedilol in escalating doses improve rate or rhythm control in patients with atrial fibrillation and fast ventricular rate?
Escalating doses of oral carvedilol appear effective and generally safe for acute rate control in atrial fibrillation with a fast ventricular response.
Answers are grounded in this paper and cite their sources.
May support escalating carvedilol for acute AF rate control; hypothesis-generating and requires randomized confirmation.
OBJECTIVE: To study the efficacy of oral carvedilol in acute treatment of atrial fibrillation (AF) with fast ventricular rate. MATERIALS AND METHODS: In an open-label, single-arm trial, oral carvedilol was administered to 35 patients of AF in escalating doses from 3.125 mg o.d. to 12.5 mg b.i.d. RESULTS: A successful result was seen in 25 patients (71.4%) with 4 converting to sinus rhythm, rate control to less than 90 bpm in 16 and a 20% rate reduction in 5 patients. Two patients developed hypotension needing withdrawal of the drug. CONCLUSION: Escalating doses of oral carvedilol can be effectively and safely used in the acute treatment of AF with fast ventricular rate.
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Chitrapu et al. (2014) studied this question.
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