Key result
Thyroid hormone administration normalized the metabolic state in spontaneously hypertensive rats and 21 hypothyroid patients (2 with hypertension) but failed to affect blood pressure.
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Spontaneously hypertensive rats (SHR) manifest a hypothyroid state as evidenced by increased thyroid weight, an increased level of plasma thyroid-stimulating hormone (TSH) and a decreased level of plasma thyroxine (T4) and triiodothyronine (T3). In 18 patients with essential hypertension, plasma TSH, T4 and T3 concentrations were all within the normal range, but the T4 level was significantly lower than in the controls. Among 21 hypothyroid patients, 2 had essential hypertension. Administration of thyroid hormone brought the metabolic state to normal in SHR and in hypothyroid patients but failed to affect the blood pressure. It is suggested that abnormality of thyroid function is neither the cause nor the accentuating factor in the development of hypertension in SH rats and in man.
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Koizumi et al. (1976) studied Essential hypertension and hypothyroidism (n=39). Thyroid hormone administration vs. Controls was evaluated on Blood pressure and thyroid function (TSH, T4, T3). Thyroid hormone administration normalized the metabolic state in spontaneously hypertensive rats and 21 hypothyroid patients (2 with hypertension) but failed to affect blood pressure.
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