Why the study?
Is Human Rhinovirus detection associated with severe pneumonia and wheezing disease in children?
Is Human Rhinovirus detection associated with severe pneumonia and wheezing disease in children?
While high background rates of HRV complicate causal attribution in infants, HRV-C detection is significantly associated with severe pneumonia and wheezing in children aged 13 to 59 months.
HRV detection confounds causal attribution in infant pneumonia; leaves open HRV-C role in wheezing among older children.
0.031) than those with HRV-A cases. Thus, the rate of HRV detection was high, with similar degrees of genetic diversity among cases and controls, confounding the interpretation of the presence of HRV in nasopharyngeal samples for attribution of a causal role in the pathogenesis of severe pneumonia in infants. However, among children 13 to 59 months of age, HRV detection, in particular, HRV-C detection, was associated with case status, especially among children with wheezing disease.
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Baillie et al. (2019) studied this question.
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