Novel Anti‐Microbial Host‐Guest Complexes Based on Cationic β‐Cyclodextrin Polymers and Triclosan/Butylparaben

The preparation of novel cationic β ‐cyclodextrin polymers (CP β CDs) and its complexes with butylparaben and triclosan were reported in this paper. FT‐IR and two‐dimensional (2D) 1 H– 1 H gradient correlated spectroscopy (gCOSY) NMR spectra confirmed that the antibiotics could be included inside the lipophilic cavities of CP β CDs. The water solubility of the antibiotics was improved significantly after inclusion with CP β CDs. The results also suggest that it was easier for butylparaben, which had relatively small molecular size, to form the complexes with CP β CDs than triclosan. Due to the targeting effect after the inclusion with cationic CP β CDs, the anti‐microbial activity of butylparaben was also enhanced substantially. However, similar improvement was not obvious for triclosan. magnified image