Decreased Insulin Secretion but Not Insulin Sensitivity in Normal Glucose Tolerant Thai Subjects

Reduced insulin secretion and insulin sensitivity has been demonstrated in normal glucose tolerant (NGT) subjects whose 2-h plasma glucose levels after an oral glucose tolerance test were 5.6–7.7 mmol/l compared with those with 2-h plasma glucose levels <5.6 mmol/l (1,2,3). These data are from high-risk ethnic subjects. Whether these data are true in Asians is uncertain. We studied insulin secretion and insulin sensitivity in 51 NGT and 15 impaired glucose …