Why the study?
Laparoscopic surgery causes a hemodynamic surge following carbon dioxide insufflation, and the relative efficacy of dexmedetomidine versus magnesium sulphate infusions in attenuating these responses needed evaluation.
Does dexmedetomidine or magnesium sulphate reduce hemodynamic surge in patients undergoing elective abdominal laparoscopic surgery under general anaesthesia?
Does dexmedetomidine or magnesium sulphate reduce hemodynamic surge in patients undergoing elective abdominal laparoscopic surgery under general anaesthesia?
Intravenous dexmedetomidine is more effective than magnesium sulphate in attenuating the cardiovascular hemodynamic surge associated with pneumoperitoneum during laparoscopic surgery.
Answers are grounded in this paper and cite their sources.
May attenuate hemodynamic response in laparoscopy; leaves open comparative efficacy versus magnesium in larger randomized trials.
The haemodynamic surge in laparoscopic surgery following carbon dioxide insufflations can be attenuated by various drugs. Dexmedetomidine, a selective-alpha-agonist depresses central sympathetic outflow producing sedation, decreased analgesic requirement, is approved by USFDA for mechanically ventilated patients in ICU for a period of <24 hours. One of its "off label" uses is attenuation of Hemodynamic changes in laparoscopic surgery. Parenteral magnesium sulphate has been used as an antiarrhythmic and antiseizure drug in preeclampsia. It also has analgesic action on NMDA receptor, inhibits catecholamine release from peripheral nociceptors and attenuates vasopressor mediated vasoconstriction. A study was conducted to assess and compare the effects of these drugs. We wanted to study the relative efficacy of infusions of dexmedetomidine & magnesium sulphate on attenuation of hemodynamic responses in laparoscopic surgery under general anaesthesia.
No takes yet. Share an insight, caveat, or question.
Mallick et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: