Recent Advances in Synthetic Aspects of Naringenin Flavonoid and its Bioprotective Effect (A Review)

Flavonoids which are secondary metabolites of plants are found naturally in fruits, vegetables, nuts, herbs, and spices, so they are important constituent of human diet also. They are also responsible for various pigments in plants and offer various health benefits to humans due to their diverse biological activities. Naringenin is a flavanone class of flavonoid and it is profusely found in citrus fruits, grapefruit, tomatoes and finds its extensive application in cosmetic industries, perfumeries as well as pharmaceutical formulations. This phytochemical has bioactive effects on human health as antioxidant, antiviral, anti-cancerous, antibacterial, anti-inflammatory, anti-obesity and hepatoprotective effects. Its anti-inflammatory and immune-stimulating actions plays a role in either preventing or control COVID infections to some extent according to recent reports. This review brings together all its synthetic routes reported till date and it also focused on the recent developments of its bioprotective effects and pharmacokinetic activities.