Miracidia of S. mansoni were promptly immobilized when placed in heated sera of hamsters and monkeys infected with this parasite. No immobilization occurred in sera from non-infected animals. The factor developed early in the infection and was still present in the sera of monkeys which had been infected with S. japonica 5 1/2 years previously. The immobilization of the miracidium appears to result from immobilization of the cilia. Cilia immobilization became less complete in high dilutions of serum and was usually confined to specific areas of the miracidium.
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L. B. Senterfit (1953) studied this question.