Why the study?
Endothelin-1 contributes to declines in endothelial function in postmenopausal women, but the effects of aerobic exercise on ET-1-mediated vasoconstriction were unknown.
Does a 12-week aerobic exercise training program improve endothelium-dependent vasodilation and reduce ET-1-mediated vasoconstriction in healthy sedentary postmenopausal women?
Does a 12-week aerobic exercise training program improve endothelium-dependent vasodilation and reduce ET-1-mediated vasoconstriction in healthy sedentary postmenopausal women?
A 12-week aerobic exercise program reduces ET-1-mediated vasoconstriction and improves endothelium-dependent vasodilation in postmenopausal women, highlighting a key mechanism for exercise-induced vascular benefits.
May improve endothelial function via ET-1 reduction in postmenopausal women; leaves open need for RCTs before clinical adoption.
Endothelin-1 (ET-1) contributes to declines in endothelial function in postmenopausal women. To our knowledge, we show for the first time that aerobic exercise reduces ET-1-mediated vasoconstriction in previously sedentary postmenopausal women. Moreover, aerobic exercise improved endothelial-dependent dilation due in part to the reductions in ET-1-mediated vasoconstriction.
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Wenner et al. (2023) studied this question.
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