What is the clinical evidence from this study?

Study design: Other. Population: Coronary neointima formation (n=36). Intervention: cRGD-loaded polymer stent vs. Unloaded polymer stents and bare metal stents. Primary outcome: Neointimal area at 12 weeks (p=0.010).

What question did this study set out to answer?

To determine whether coronary stents coated with an integrin-binding cyclic Arg-Gly-Asp (cRGD) peptide accelerate endothelialization and reduce neointimal hyperplasia by recruiting endothelial progenitor cells.

August 5, 2026Journal of the American College of CardiologyOpen Access

A Novel Drug-Eluting Stent Coated With an Integrin-Binding Cyclic Arg-Gly-Asp Peptide Inhibits Neointimal Hyperplasia by Recruiting Endothelial Progenitor Cells

Q: What are the key findings of this study?

At 12 weeks, cRGD-loaded stents significantly reduced neointimal area (2.2 vs 3.8 mm2) and percent area stenosis (33% vs 54%) compared with polymer stents (p=0.010) in porcine coronary arteries.

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Key result

cRGD-loaded stents reduce neointimal area ~42% vs polymer stents at 12 weeks in pigs.

P=0.010
n=36

Why the study?

Does a cRGD-coated stent reduce neointimal hyperplasia compared to bare metal or polymer stents in a porcine coronary artery model?

Population

Porcine coronary arteries and in vitro endothelial progenitor cells

Comparison

Guidant Tetra stents with a durable polymer… vs Unloaded polymer stents and bare metal stents

Design

Preclinical

Follow-up

12 weeks

Authors

RBRüdiger BlindtKrankenhaus vom Roten Kreuz FVFelix VogtUniversitätsklinikum Aachen IAIrina AstafievaMaxygen (United States)

Discussion

Member takes

Implication

Stent coating with cRGD reduces in-stent restenosis in a porcine model by accelerating endothelialization.

Key Points

To determine whether coronary stents coated with an integrin-binding cyclic Arg-Gly-Asp (cRGD) peptide accelerate endothelialization and reduce neointimal hyperplasia by recruiting endothelial progenitor cells.
Evaluated endothelial progenitor cell (EPC) outgrowth, recruitment under flow conditions, and migration in vitro using cRGD coatings.
Implanted 12 cRGD-loaded polymer stents (67 µg cRGD per stent), 12 unloaded polymer stents, and 12 bare metal stents into porcine coronary arteries with follow-up at 4 and 12 weeks.
Quantified cRGD tissue clearance via HPLC-mass spectrometry, evaluated endothelial coverage using CD34 immunostaining and electron microscopy, and tracked infused EPC recruitment after 7 days.
At 12 weeks, cRGD-coated stents significantly reduced neointimal area to 2.2 ± 0.3 mm² compared to polymer (3.8 ± 0.4 mm², p = 0.010) and bare metal stents (3.8 ± 0.3 mm², p < 0.001).
Percent area stenosis at 12 weeks was significantly lower in the cRGD group (33 ± 5%) versus polymer (54 ± 6%, p = 0.010) and bare metal stents (53 ± 3%, p < 0.001).
Stents showed no differences in neointima at 4 weeks, but cRGD-loaded stents exhibited enhanced early CD34-positive endothelial coverage and increased early recruitment of infused EPCs.

Structured PICO

Does a cRGD-coated stent reduce neointimal hyperplasia compared to bare metal or polymer stents in a porcine coronary artery model?

Population

36 stents (cRGD-loaded, unloaded polymer, and bare metal) deployed in porcine coronary arteries and followed for up to 12 weeks.

Intervention

Guidant Tetra stents with a durable polymer coating containing 67 microg cRGD (integrin-binding cyclic Arg-Gly-Asp peptide) per stent

Comparator

Unloaded polymer stents and bare metal stents

Outcome

Neointimal area and percent area stenosis assessed by histomorphometry at 4 and 12 weekssurrogate

Main Result

Absolute Event Rate: 2.2% vs 3.8%

p-value: p=0.010

Stent coating with cRGD reduces in-stent restenosis in a porcine model by accelerating endothelialization.

Cite This Study

Blindt et al. (2006) studied Coronary neointima formation (n=36). cRGD-loaded polymer stent vs. Unloaded polymer stents and bare metal stents was evaluated on Neointimal area at 12 weeks (p=0.010). At 12 weeks, cRGD-loaded stents significantly reduced neointimal area (2.2 vs 3.8 mm2) and percent area stenosis (33% vs 54%) compared with polymer stents (p=0.010) in porcine coronary arteries.

synapsesocial.com/papers/6a73a8c1e284bada359dfbc6 https://doi.org/10.1016/j.jacc.2005.11.081

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August 5, 2026Journal of the American College of CardiologyOpen Access

A Novel Drug-Eluting Stent Coated With an Integrin-Binding Cyclic Arg-Gly-Asp Peptide Inhibits Neointimal Hyperplasia by Recruiting Endothelial Progenitor Cells

View Full Paper

Ask AI

Bookmark

Key result

cRGD-loaded stents reduce neointimal area ~42% vs polymer stents at 12 weeks in pigs.

P=0.010
n=36

Why the study?

Does a cRGD-coated stent reduce neointimal hyperplasia compared to bare metal or polymer stents in a porcine coronary artery model?

Population

Porcine coronary arteries and in vitro endothelial progenitor cells

Comparison

Guidant Tetra stents with a durable polymer… vs Unloaded polymer stents and bare metal stents

Design

Preclinical

Follow-up

12 weeks

Authors

RBRüdiger BlindtKrankenhaus vom Roten Kreuz FVFelix VogtUniversitätsklinikum Aachen IAIrina AstafievaMaxygen (United States)

Discussion

Member takes

Implication

Stent coating with cRGD reduces in-stent restenosis in a porcine model by accelerating endothelialization.

Key Points

To determine whether coronary stents coated with an integrin-binding cyclic Arg-Gly-Asp (cRGD) peptide accelerate endothelialization and reduce neointimal hyperplasia by recruiting endothelial progenitor cells.
Evaluated endothelial progenitor cell (EPC) outgrowth, recruitment under flow conditions, and migration in vitro using cRGD coatings.
Implanted 12 cRGD-loaded polymer stents (67 µg cRGD per stent), 12 unloaded polymer stents, and 12 bare metal stents into porcine coronary arteries with follow-up at 4 and 12 weeks.
Quantified cRGD tissue clearance via HPLC-mass spectrometry, evaluated endothelial coverage using CD34 immunostaining and electron microscopy, and tracked infused EPC recruitment after 7 days.
At 12 weeks, cRGD-coated stents significantly reduced neointimal area to 2.2 ± 0.3 mm² compared to polymer (3.8 ± 0.4 mm², p = 0.010) and bare metal stents (3.8 ± 0.3 mm², p < 0.001).
Percent area stenosis at 12 weeks was significantly lower in the cRGD group (33 ± 5%) versus polymer (54 ± 6%, p = 0.010) and bare metal stents (53 ± 3%, p < 0.001).
Stents showed no differences in neointima at 4 weeks, but cRGD-loaded stents exhibited enhanced early CD34-positive endothelial coverage and increased early recruitment of infused EPCs.

Structured PICO

Does a cRGD-coated stent reduce neointimal hyperplasia compared to bare metal or polymer stents in a porcine coronary artery model?

Population

36 stents (cRGD-loaded, unloaded polymer, and bare metal) deployed in porcine coronary arteries and followed for up to 12 weeks.

Intervention

Guidant Tetra stents with a durable polymer coating containing 67 microg cRGD (integrin-binding cyclic Arg-Gly-Asp peptide) per stent

Comparator

Unloaded polymer stents and bare metal stents

Outcome

Neointimal area and percent area stenosis assessed by histomorphometry at 4 and 12 weekssurrogate

Main Result

Absolute Event Rate: 2.2% vs 3.8%

p-value: p=0.010

Stent coating with cRGD reduces in-stent restenosis in a porcine model by accelerating endothelialization.

Cite This Study

synapsesocial.com/papers/6a73a8c1e284bada359dfbc6 https://doi.org/10.1016/j.jacc.2005.11.081

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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