Why the study?
Does dopamine transporter genotype affect intrinsic functional connectivity depending on cognitive state?
Population
Subjects with different dopamine transporter genotypes (10/10 homozygotes vs 9/10 heterozygotes)
Comparison
Working memory task vs Rest state
Design
Cross-sectional
Authors
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DAT1 genotype may modulate task-state connectivity; hypothesis-generating for executive endophenotypes, needs replication before clinical consideration.
Does dopamine transporter genotype affect intrinsic functional connectivity depending on cognitive state?
Dopamine transporter genotype modulates cross-network functional connectivity during working memory, validating it as an endophenotype of executive dysfunction.
Gordon et al. (2011) studied this question.
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