Transition metal complexes of 3-acetylpyridine ⁴ N-(2-pyridyl)thiosemicarbazone (HAPS); structural, spectroscopic, and biological studies

This work examines transition metal ion complexes which have been synthesized from 3-acetylpyridine 4 N-(2-pyridyl)thiosemicarbazone (HAPS) (1). [Cu(HAPS)2Cl2] · H2O (2), [Hg(HAPS)2Cl2] (3), [Ni(HAPS)Cl2] · 2H2O (4), [UO2(APS)2] · 2H2O (5), [VO(HAPS)2]SO4 · H2O (6), and [Zn(HAPS)2Cl2] (7) were characterized by elemental analysis, spectral (IR, 1H-NMR, and UV-Vis), magnetic, and molar conductance measurements. The biochemical studies showed that 2 and 3 have powerful and complete degradation on both DNA and protein. Complexes 2, 4, and 7 showed significant antioxidant properties, especially scavenging on superoxide and hydroxyl radicals. The antibacterial screening demonstrated that all studied complexes have maximum and broad range activities against Gram-positive and Gram-negative bacterial strains.