Various 3-phenyl-2-piperazinylquinolines and their 3-methyl analogs were synthesized and the effects of these compounds on the central nervous system were evaluated pharmacologically in mice. Some compounds having a 3-phenyl group showed potent antagonism of maximal electroshock seizures, but the 3-methyl analogs had no significant activity in any of the tests.
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Hino et al. (1987) studied this question.
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