Vasovagal syncope in young subjects is driven by early failure of vascular resistance and withdrawal of sympathetic outflow to skeletal muscle blood vessels.
Reinforces sympathetic withdrawal in vasovagal syncope; leaves open targeted therapies pending prospective trials.
The occurrence of vasovagal fainting is common in young subjects, but the origin of the precipitating hemodynamic mechanisms involved remain a subject of considerable speculation. Vasovagal fainting is not a sudden onset phenomenon, early failure of vascular resistance responses occurs in faint-prone young subjects. The variability of hemodynamic responses during the actual faint is large, but the main mechanism operative during, is withdrawal of sympathetic outflow to blood vessels in skeletal muscle with impairment of ability to maintain vasomotor tone.
No takes yet. Share an insight, caveat, or question.
Wieling et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: