Why the study?
The study aimed to systematically review randomized clinical trials evaluating the effects of resveratrol supplementation on vascular flow-mediated dilation.
Does resveratrol supplementation improve vascular flow-mediated dilation in subjects with cardio-metabolic risk factors?
Does resveratrol supplementation improve vascular flow-mediated dilation in subjects with cardio-metabolic risk factors?
Resveratrol supplementation may improve endothelial function as measured by flow-mediated dilation in patients with cardio-metabolic risk factors.
Resveratrol may improve endothelial function; leaves open need for larger, longer RCTs before clinical adoption.
Purpose This study aims to systematically review randomized clinical trials (RCTs) evaluated the effects of resveratrol on vascular flow-mediated dilation (FMD). Design/methodology/approach All published RCTs in English were systematically searched on PubMed and Scopus search engines up to October 2017. A total of 61 studies were found through search databases. The outcome variable of interest was FMD. Six articles which met inclusion criteria were included in this study. Findings From six studies, four showed a significant improvement in FMD after resveratrol supplementation acutely or chronically in subjects with cardio-metabolic risk factors. Two other studies did not show any significant effect of resveratrol on FMD. Originality/value The authors systematically reviewed the effectiveness of resveratrol supplementation on FMD for the first time. The findings suggest that pure resveratrol supplementation may have beneficial effects on endothelium dependent vasodilatation indicator, FMD.
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Emamat et al. (2018) studied this question.
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