Answers are grounded in this paper and cite their sources.
A tryptic [EC 3.4.21.4] digestion assay of 2-aminoisobutyric acid (Aib)-containing peptides was carried out to investigate the effect of alpha,alpha-dialkyl amino acid residues on the protease resistance. The introduction of Aib residues to the P1' positions exhibited a 19-fold higher protease resistance than the peptide with Aib residues introduced to the P2 position or the non-Aib peptide. The peptide having Aib residues introduced to the P1' and P2 positions resulted in complete resistance.
No takes yet. Share an insight, caveat, or question.
Yamaguchi et al. (2003) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: