Prostate-Specific Membrane Antigen PET/Magnetic Resonance Imaging for the Planning of Salvage Radiotherapy in Patients with Prostate Cancer with Biochemical Recurrence After Radical Prostatectomy

sRT is a potentially curative treatment option for patients with prostate cancer with BCR after RP, especially when PSA levels are still low. Because of a lack of sensitive conventional imaging methods, the planning of sRT is currently being performed in the absence of visual evidence of the site of recurrence. Simultaneous PSMA PET/MR imaging combines excellent soft tissue contrast with a superior sensitivity for cancer, and can help detect recurrence in the prostate bed, lymph nodes, bones, and distant organs. Consequently, PSMA PET/MR imaging can play an important role in the selection of patients who may benefit from sRT, and facilitate dose-escalated and metastases-directed treatment planning. Whether or not PSMA PET/MR imaging–based planning of sRT can improve the long-term outcome in patients with BCR after RP should be answered in prospective randomized controlled trials.