Background and Objective: The up-regulation of heme oxygenase-1 (HO-1) has been reported to protect from ischemia-reperfusion (I/R) injury and nootkatone, a pharmacologically active ingredient found in the rhizomes of Cyperus rotundus has been reported to induce HO-1 in immune cells. The aim of the present study was to determine whether the protective effect of C. rotundus extract and its constituent, nootkatone against myocardial I/R injury is due to its antioxidant and anti-inflammatory effects.
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Chang et al. (2016) studied this question.
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