Cyproheptadine Treatment of Nelson′s Syndrome: Restoration of Plasma Acth Circadian Periodicity and Reversal of Response to Trf¹,²

Administration of cyproheptadine for four months to a patient with Nelson's Syndrome was associated with evidence of skin lightening, decreased plasma ACTH concentrations, return of a normal circadian periodicity of plasma ACTH concentrations, and lack of responsiveness of plasma ACTH concentrations to TRF administration, in contrast to the response seen in the untreated state.