Key result
Fructosamine correlates moderately with affinity HbA1, matching clinical control category in ~71% of diabetes patients.
Cross-Sectional (n=204)
No
The relative value of fructosamine as an alternative to glycosylated hemoglobin (HbA1) and other measures of glycemic control was assessed in 100 insulin-dependent (IDDM) and 104 non-insulin-dependent (NIDDM) diabetic patients. We measured HbA1 (by electrophoretic and affinity methods), plasma glucose, glycosylated plasma proteins, and fructosamine in blood taken at a single clinic visit. The values were compared both by correlation analysis and by considering whether the various indices of glycemic control placed the patients in the same clinical decision categories as they were in by the HbA1 (affinity) result. Fructosamine correlated moderately well with HbA1 (affinity; r = .8) and placed 71% of IDDM and 72% of NIDDM patients in the same clinical category of good, moderate, or poor control. Differences can probably be partly attributed to the different periods over which HbA1 and fructosamine reflect average glycemia and partly to imprecision.
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Smart et al. (1988) conducted a cross-sectional in Diabetes mellitus (insulin-dependent and non-insulin-dependent) (n=204). Fructosamine measurement vs. Glycosylated hemoglobin (HbA1), plasma glucose, and glycosylated plasma proteins was evaluated on Correlation with HbA1 (affinity) and concordance in clinical decision categories of glycemic control (r = 0.8). Fructosamine correlated moderately well with affinity HbA1 (r = 0.8) and classified 71% of IDDM and 72% of NIDDM patients into the same clinical control category.
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