Why the study?
Chaihujialonggumuli granule has anti-inflammatory and tranquilizing properties, but the mechanism underlying its cardioprotective and anxiolytic efficacy after myocardial infarction remained unknown.
Does Chaihujialonggumuli granule improve cardiac function and reduce anxiety in rats after acute myocardial infarction?
Population
Rats after left coronary artery ligation
Comparison
Chaihujialonggumuli granule (BFG) vs complex group and sham group
Design
Animal study
Authors
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BFG may attenuate post-MI inflammation and anxiety via CXCR4/NLRP3; leaves open clinical translation pending human trials.
Does Chaihujialonggumuli granule improve cardiac function and reduce anxiety in rats after acute myocardial infarction?
Chaihujialonggumuli granule may reduce inflammation and treat co-existing anxiety after myocardial infarction through inhibition of the CXCR4/NF-κB/GSDMD signaling pathway in a rat model.
Hou et al. (2020) studied this question.
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