Why the study?
Vagus nerve neuropathy increases the risk of arrhythmias and sudden death, creating a need for a selective test of vagus nerve function.
Does the novel vagus nerve neurodynamic test (VN-NDT) induce heart rate reduction and accurately detect autonomic symptoms in healthy subjects?
Does the novel vagus nerve neurodynamic test (VN-NDT) induce heart rate reduction and accurately detect autonomic symptoms in healthy subjects?
Answers are grounded in this paper and cite their sources.
The novel vagus nerve neurodynamic test is a valid and accurate method for detecting vagus nerve activation, inducing significant heart rate reductions in healthy subjects of both sexes.
Background The vagus nerve (VN), also called the pneumogastric nerve, connects the brainstem to organs contained in the chest and abdomen. Physiologically, VN stimulation can rapidly affect cardiac activity and heart rate (HR). VN neuropathy can increase the risk of arrhythmias and sudden death. Therefore, a selective test of VN function may be very useful. Since peripheral neurodynamic tests (NDT) are reliable for the assessment of neuropathies in somatic nerves, we aimed to validate a novel NDT to assess VN activity, namely, the VN-NTD. Methods In this cross-sectional double-blind, sex-balanced study, 30 participants (15 females) completed a checklist of autonomic dysfunction symptoms. During the VN-NDT administration, HR and symptoms (i.e., mechanical allodynia) were monitored in parallel to a real-time ultrasonography imaging (USI) and motion capture analysis of the neck. The VN-NDT impact on HR and its accuracy for autonomic symptoms reported in the last 7 days were tested. Results The VN-NDT induced a significant HR reduction of about 12 and 8 bpm in males and females [ t (1, 119) = 2.425; p < 0.017; η p 2 = 0.047, 95% confidence interval (CI): 0.93–9.18], respectively. No adverse events were observed during VN-NDT. A substantial interexaminer agreement between the evaluators in symptoms induction by VN-NDT was detected [ F (1, 119) = 0.540; p = 0.464; η p 2 = 0.005, low effect]. Notably, mechanical allodynia accuracy for gastrointestinal dysfunctions was excellent ( p < 0.05; 95% CI: 0.52–0.73; p < 0.001; 95% CI: 0.81–0.96). Conclusions The novel VN-NDT is a valid and accurate test capable of detecting VN activation with high sensitivity. Data provided are suitable for both sexes as a hallmark of HR variation due to VN normal response. The proposed VN-NDT may be reliable as daily routine neurological examination tests for the evaluation of neuropathic signs related to neuroinflammation of the VN. Clinical Trial Registration www.ClinicalTrials.gov , identifier NCT04192877.
No takes yet. Share an insight, caveat, or question.
Carta et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: