Failure To Develop HIV Infection after Receipt of HIV-Contaminated Blood and Postexposure Prophylaxis

Brief Communications4 July 2000Failure To Develop HIV Infection after Receipt of HIV-Contaminated Blood and Postexposure ProphylaxisTerese L. Katzenstein, MD, PhD, Ebbe Dickmeiss, MD, DrMedSci, Hassan Aladdin, MSc, Adam Hede, MD, Claus Nielsen, MSc, PhD, Helle Nielsen, BA, Louise B. Jørgensen, MSc, PhD, and Jan Gerstoft, MD, DrMedSciTerese L. Katzenstein, MD, PhDFrom National University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark.Search for more papers by this author, Ebbe Dickmeiss, MD, DrMedSciFrom National University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark.Search for more papers by this author, Hassan Aladdin, MScFrom National University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark.Search for more papers by this author, Adam Hede, MDFrom National University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark.Search for more papers by this author, Claus Nielsen, MSc, PhDFrom National University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark.Search for more papers by this author, Helle Nielsen, BAFrom National University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark.Search for more papers by this author, Louise B. Jørgensen, MSc, PhDFrom National University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark.Search for more papers by this author, and Jan Gerstoft, MD, DrMedSciFrom National University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-1-200007040-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Use of HIV-antibody screening of blood donated for transfusions has reduced the risk for HIV transmission. However, because of the lag time between acquisition of HIV infection and development of antibodies (the window period), some HIV-infected blood donors escape detection (1, 2). Currently, the window period is estimated to be 3 weeks (3). We report a case in which transfusion of HIV RNA–positive, HIV-seronegative blood did not lead to infection in the recipient, most likely because potent postexposure antiretroviral therapy was initiated promptly and followed thoroughly.Case ReportPatient D-1 developed fever and a follicular confluent rash. No exposure to ...References1. Cumming PD, Wallace EL, Schorr JB, Dodd RY. Exposure of patients to human immunodeficiency virus through the transfusion of blood components that test antibody-negative. N Engl J Med. 1989;321:941-6. CrossrefMedlineGoogle Scholar2. Lackritz EM, Satten GA, Aberle-Grasse J, Dodd RY, Raimondi VP, Janssen RS, et al . Estimated risk of transmission of the human immunodeficiency virus by screened blood in the United States. N Engl J Med. 1995;333:1721-5. CrossrefMedlineGoogle Scholar3. Schreiber GB, Busch MP, Kleinman SH, Korelitz JJ. The risk of transfusion-transmitted viral infections. The Retrovirus Epidemiology Donor Study. 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Prevention of SIV infection in macaques by (R)-9-(2-phosponylmethoxypropyl)adenine. Science. 1995;270:1197-9. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Terese L. Katzenstein, MD, PhD; Ebbe Dickmeiss, MD, DrMedSci; Hassan Aladdin, MSc; Adam Hede, MD; Claus Nielsen, MSc, PhD; Helle Nielsen, BA; Louise B. Jørgensen, MSc, PhD; Jan Gerstoft, MD, DrMedSciAffiliations: From National University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark.The data were first reported at the Third International Workshop on HIV Drug Resistance & Treatment Strategies, San Diego, California, 23–26 June 1999 (Antiviral Therapy. 1999;4[Suppl 1]:124).Acknowledgment: The authors thank Jesper Eugen-Olsen for performing the CCR5 genotyping.Corresponding Author: Terese L. Katzenstein, MD, PhD, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø , Denmark; e-mail, [email protected]dk.Current Author Addresses: Drs. Katzenstein, Aladdin, and Gerstoft and Ms. Nielsen: Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø , Denmark.Dr. Dickmeiss: Department of Clinical Immunology, National University Hospital Rigshospitalet, Tagensvej 20, DK-2200 Copenhagen, Denmark.Dr. Hede: Department of Pediatric Orthopedic Surgery, National University Hospital Rigshospitalet, Tagensvej 20, DK-2200 Copenhagen, Denmark.Drs. Nielsen and Jørgensen: Retrovirus Laboratory, State Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark.