A new type of protective microcontainer, capable of preventing oxidation of encapsulated compounds by low molecular weight oxidizing agents, was demonstrated. These microcontainers (microcapsules) are hollow spheres with the shell made of layer-by-layer assembled polyelectrolytes with an engineered outermost layer. The protecting ability of the developed polyelectrolyte capsules was monitored by oxidation of encapsulated bovine serum albumin by H 2 O 2 dissolved in aqueous solution. Different catalysts for H 2 O 2 decomposition (catalase, Fe 3 O 4 nanoparticles) were deposited onto the polyelectrolyte shell to increase the protection efficiency. The highest protection activity was observed for poly(allylamine)/poly(styrene sulfonate) capsules containing nano-Fe 3 O 4 in the polyelectrolyte shell.
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Shchukin et al. (2004) studied this question.
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