Why the study?
Does a 2-h serial multiple biomarker protocol accurately exclude myocardial infarction in patients presenting to the emergency department with suspected acute coronary syndrome?
Population
1758 patients undergoing evaluation for possible myocardial infarction in the Emergency Department
Comparison
2-h serial multiple biomarker protocol combined… vs Standard 8-12 h troponin
Design
Cohort
Follow-up
30 days
Authors
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May support combined SMB-TIMI use to identify lower-risk ED patients; observational data leaves open need for prospective validation before practice change.
Does a 2-h serial multiple biomarker protocol accurately exclude myocardial infarction in patients presenting to the emergency department with suspected acute coronary syndrome?
A 2-hour serial multiple biomarker protocol is not sufficiently sensitive on its own to exclude myocardial infarction, but may identify lower-risk patients when combined with clinical risk scoring.
Macdonald et al. (2012) studied this question.
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