Why the study?
Does the left-to-right ventricular stroke index ratio from gated cardiac blood pool scans accurately measure the severity of valvular regurgitation compared to qualitative angiography in patients with mitral and/or aortic regurgitation?
Does the left-to-right ventricular stroke index ratio from gated cardiac blood pool scans accurately measure the severity of valvular regurgitation compared to qualitative angiography in patients with mitral and/or aortic regurgitation?
Gated cardiac blood pool scans provide a reliable, noninvasive method to assess the severity of aortic and mitral regurgitation by comparing left and right ventricular stroke volume indices.
Supports gated scans for noninvasive regurgitation grading; leaves open quantitative prospective validation.
A simple, noninvasive radionuclide technique which measures the severity of valvular regurgitation has been developed. The technique compares right and left ventricular stroke volume indices (change in counts between diastole and systole over the left and right ventricles) from 45 degrees LAO gated cardiac blood pool scans. In 14 control subjects, the left-to-right ventricular stroke index ratio was near unity (1.15 +/- 0.15 [SD]). In 26 patients with mitral and/or aortic regurgitation it was larger (range 1.36--5.30, mean 2.44). Comparison between the stroke index ratio and qualitative angiographic estimates of regurgitation revealed good agreement (F = 45.5, p less than 0.001). Gated cardiac blood pool scans permit noninvasive assessment of the severity of valvular regurgitation.
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Rigo et al. (1979) studied this question.
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