Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia. Physiologically based pharmacokinetic (PBPK) modeling offers a unique modality to incorporate multiple levels of information to estimate age‐specific pharmacokinetics. This tutorial will serve to provide the reader with a basic understanding of the procedural steps to developing a pediatric PBPK model and facilitate a discussion of the advantages and limitations of this modeling technique. CPT Pharmacometrics Syst. Pharmacol . (2014) 3, e148; doi: 10.1038/psp.2014.45 ; published online 19 November 2014
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Maharaj et al. (2014) studied this question.
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